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刘玉明
2023-02-22 14:24:08   审核人:   (点击: )


刘玉明简介

姓名

刘玉明

性别

出生年月

1968.07

学历学位

博士

 

职称

教授

系别

制药工程系

导师类型

硕导

电话

13702182883

Email

liuyuming@tjut.edu.cn

办公/科研室

19号楼407室

所属学科

100701药物化学;086000生物与医药070300化学;

085600材料与化工

研究

方向

1. 具有重要生物活性天然先导化合物的发现及优化;

2. 针对重大疾病的创新药物研制;

3. 上市药品的质量标准提升和生产工艺改进。

讲授课程:本科生课程:天然药物化学;研究生课程:植化方法学

主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等):

科研项目: 

1. 国家自然科学基金面上项目:贝母属植物中多靶向抗阿尔茨海默病活性成分及作用机制研究(31970373), 2020.01-2023.12,58万,项目负责人;

2. 国家自然科学基金面上项目:维药斯亚旦抗肝癌药效物质基础研究(81073153), 2011.01-2013.1232万,项目负责人;

3. 天津市科技发展计划项目:35种植物药标准提取物的研究(05ZHGCGX01500),2005.04-2007.0350万,参加;

4. 国家自然科学基金项目:民族药马蹄金生物活性成分的研究(39960081),2000.01-2002.1212万,参加; 

5. 教育部“国家级大学生创新创业训练计划项目”:维吾尔药斯亚旦中抗肝癌先导物的发现(201210060001),2012.09-2014.072万,指导教师;

6. 天津市教委科研项目:两亲性树型共聚物的分子设计及其多功能靶向药物载体的构建(20110501),2011.11-2014.104万,参加。

论文:

1. An-Wen Wang, Yu-Ming Liu*, Ming-Ming Zhu, Rui-Xue Ma. Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer’s disease: Isolation, structural elucidation and biological activity. Phytochemistry, 2022, 201: 113279.

2. Cheng Liu, Li-Ning Wang, Yu-Ming Liu*. Novel morpholine-bearing quinoline derivatives as potential cholinesterase inhibitors: The influence of amine, carbon linkers and phenylamino groups. International Journal of Molecular Sciences, 2022, 23(19): 11231.

3. Yu-Ming Liu, Jing-Jing Fan, Li-Ning Wang. Discovery of guanidine derivatives from Buthus martensii Karsch with metal-binding and cholinesterase inhibition properties. Molecules, 2021, 26 (21): 6737.

4. Xiao Liu, Lu Sun, Qing-Hua Liu, Bao-Quan Chen*, Yu-Ming Liu*. Synthesis, characterization and anti-hepatoma activity of new hederagenin derivatives. Mini-Reviews in Medicinal Chemistry, 2020, 20 (3): 252-257.

5. Rong Cai, Li-Ning Wang, Jing-Jing Fan, Shang-Qi Geng, Yu-Ming Liu*. New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer’s disease. Bioorganic Chemistry, 2019, 93: 103328.

6. Jun Zhu, Li-Ning Wang, Rong Cai, Shang-Qi Geng, Ya-Fei Dong, Yu-Ming Liu*. Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment. Bioorganic & Medicinal Chemistry Letters, 2019, 29(11): 1325-1329.

7. Hai-Ying Liu, Hai-Xin Wang, Xin Li, Zheng Wu, Cai-Wen Li, Yu-Ming Liu*, Wei Li, Bao-Quan Chen*. Synthesis, antitumor and antimicrobial evaluation of novel 1,3,4-thiadiazole derivatives bearing disulfide bond. Medicinal Chemistry Research, 2018, 27(8): 1929-1940.

8. Cheng-Long Li, Yu-Ming Liu, Zhe Sun, Jin-Yun Zhang, Mei-Yan Liu, Chen Zhang, Qian Zhang, Hong-Juan Wang, Xu-Guang Liu. Synthesis, characterization, and properties of bis-BN ullazines. Organic Letters, 2018, 20 (10): 2806–2810.

9. Yu-Ming Liu, Ya-Dong Feng, Xi Lu, Jian-Bing Nie, Wei Li, Li-Ning Wang,Li-Jun Tian, Qing-Hua Liu. Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii. European Journal of Medicinal Chemistry, 2017, 137: 280-291. 

10. Yu-Ming Liu, Jian-Bing Nie, Lin-Na Sun, Qing-Hua Liu. Cytotoxic compounds from Scolopendra subspinipes mutinlans. Heterocycles, 2016, 92 (2): 346-352.

11. Bao-Lin Li, Bo Li, Rui-Lian Zhang, Ji-Jun Zhao, Xue-Feng Wang, Yu-Ming Liu, Yan-Ping Shi, Jin-Biao Liu, Bao-Quan Chen. Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold. Bioorganic & Medicinal Chemistry Letters, 2016, 26 (4): 1279-1281. 

12. Xiao-Yun Fu, Sha Li, Fen Jing,_Xue-Feng Wang, Bao-Lin Li, Ji-Jun Zhao, Yu-Ming Liu, Bao-Quan Chen. Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold as potential antitumor agents. Medicinal Chemistry, 2016, 12 (7): 631-639.

13. Lu Sun, Yu-Ming Liu*, Bao-Quan Chen, Qing-Hua Liu. New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells. Bioorganic & Medicinal Chemistry Letters, 2015, 25 (18): 3864-3866.

14. Li-Na Xuan, Peng Wang, Kai Zhang, Yan-Ping Shi, Yu-Ming Liu, Tao Zhu, Bao-Quan Chen. Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone derivatives. Medicinal Chemistry Research, 2015, 24 (2): 543-552.

15. Jie Zhao, Li-Na Xuan, Hai-Chuan Zhao, Ji Chen, Xiao-Yun Fu, Sha Li, Fen Jing, Yu-Ming Liu, Bao-Quan Chen. Synthesis and antitumor activities of 1,3,4-thiadiazole derivatives possessing benzisoselenazolone scaffold. Chemical Research in Chinese Universities, 2014, 30(5), 764-769.

16. Kai Zhang, Peng Wang, Li-Na Xuan, Xiao-Yun Fu, Fen Jing, Sha Li, Yu-Ming Liu, Bao-Quan Chen. Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety. Bioorganic & Medicinal Chemistry Letters, 2014, 24 (22): 5154-5156.

17. Yu-Ming Liu, Yu-Hu Jiang, Qing-Hua Liu, Bao-Quan Chen. Indazole-type alkaloids from the seeds of Nigella glandulifera. Phytochemistry Letters, 2013, 6 (4): 556559.

18. Yu-Ming Liu, Lu Sun, Qing-Hua Liu, Shi-Rong Lu, Bao-Quan Chen. Dolabellane-type diterpene alkaloids from Nigella glandulifera. Biochemical Systematics and Ecology, 2013, 49: 43–46.

19. Ying-Li Chen, Chun-Lan Zhou, Zhen-Dan Ge, Yu-Fa Liu, Yu-Ming Liu, Wei-Yi Feng, Sen Li, Guo-You Chen, Tai-Ming Wei. Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense. Oncology Letters, 2013, 6 (4): 11401146. 

20. Hai-Chuan Zhao, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, Li-Na Xuan, Peng Wang, Kai Zhang, Bao-Quan Chen. Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives. Bioorganic & Medicinal Chemistry Letters, 2013, 23 (24): 6577-6579.

21. Yu Feng, Yu-Ming Liu*, Qing-Hua Liu, Ying-Jie Lei. Nigelactone, new phthalide glucoside from the seeds Nigella glandulifera. Heterocycles, 2012, 85 (12): 3015-3019.

22. Jie Zhao, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Hai-Chuan Zhao, Ji Cheng. Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone. Chinese Chemical Letters, 2012, 23 (7): 817-819.

23. Zhen-Hua Luo, Shuang-Yan He, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, and Qiu-Sheng Wang. Synthesis and in Vitro Antitumor Activity of 1,3,4-Oxadiazole Derivatives Based on Benzisoselenazolone. Chemical & Pharmaceutical Bulletin, 2012, 60 (7): 887–891.

24. Zhen-Hua Luo, Bao-Quan Chen, Shuang-Yan He, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li. Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives. Bioorganic & Medicinal Chemistry Letters, 2012, 22 (9): 3191-3193.

25. Yu-Ming Liu, Qing-Hua LiuBao-Quan Chen. A new flavonol glycoside from the seeds of Nigella glandulifera. Natural Product Research, 2011, 25 (14):1334-1338.

26. Ze Tian, Yu-Ming Liu, Si-Bao Chen, Jun-Shan Yang, Pei-Gen Xiao, Liao Wang, Erxi Wu. Cytotoxicity of two triterpenoids from Nigella glandulifera, Molecules, 2006, 11 (9): 693-699.

27. Yu-Ming Liu, Jun-Shan Yang, Qing-Hua Liu. A new alkaloid and its artificial derivative with indazole ring from Nigella glandulifera. Chemical & Pharmaceutical Bulletin, 2004, 52 (4): 454-455.

28. 张淑丽,刘玉明*.贝母属植物化学成分及药理活性研究进展. 中华中医药学刊2022,4011):180-184.

29. 王安汶,刘玉明*.异甾体生物碱类化合物及药理活性研究进展.天然产物研究与开发,2022,341):164-175.

30. 刘玉明,姜海燕,陈宝泉,雷英杰,牛心蕙.天然药物化学教学与文化传承培养的思考.教育现代化2019,6(83):23-25.

31. 刘玉明,田丽珺,胡栋,聂建兵. 4-N-苯胺基喹啉衍生物的合成及胆碱酯酶抑制活性.高等学校化学学报,2017, 38(3):392-397. 

32. 艾双艳,李卫国,冯亚东,田丽珺,刘玉明*.全蝎化学成分的研究.中成药2017, 39(8): 1639-1641.

33. 史林琦,路熹,孟令武,吕文婷,刘庆华,刘玉明*.新疆贝母鳞茎化学成分的分离与鉴定.中药材2017, 40(9): 2098-2100.

34. 李静,刘玉明*,刘庆华,李微.瘤果黑种草子中磷脂类成分的研究.中成药,2015,37(1):128-131.

35. 刘玉明,蒋玉虎,张海滨.小儿清肺颗粒质量标准研究.中药新药与临床药理,2014,25(5):610-614.

36. 蒋玉虎,刘玉明*,孙璐,李静.炉贝母不同提取物中贝母辛和贝母素乙含量的HPLC-ELSD测定.时珍国医国药,2014, 25(5):1051-1053.

37. 刘玉明,路熹,蒋玉虎,刘庆华,高继光. HPLC-ELSD同时测定新疆贝母中贝母辛和贝母素乙的含量.中药材,2014, 37(5):827-829.

38. 刘玉明,郑丽萍,王家美. 秦艽中龙胆苦苷纯化工艺的正交实验法优选.时珍国医国药,2012, 23(7):1596-1598.

39. 刘玉明,李彩文. 天然药物化学教学方法的探讨.中国医药导报,2011,8(26):120-122.

40. 史艳萍, 陈宝泉, 麻静, 刘玉明, 李彩文. 2-(2-取代-1,3,4-噻二唑-5-基)-苯并异硒唑-3(2H)-酮衍生物的合成及体外抗癌活性, 化学学报2011, 69(21): 2561-2566.

41. 杨梅,刘玉明,高瑞昶. 高效液相色谱法测定桑叶中1-脱氧野尻霉素的含量.武警医学,2007,18(2):121-123.

42. 刘玉明,杨峻山,刘庆华. 瘤果黑种草子化学成分的研究.中国中药杂志,2005,30(13):980-983.

43. 刘玉明,杨峻山,刘庆华. 红花化学成分研究.中药材,2005,28(4):288-289.

44. 梁光义,刘玉明,曹佩雪,徐必学,郝小江. 民族药马蹄金中多羟基化合物的研究.中南药学,2003,1(2):105-107.

45. 刘玉明,梁光义,徐必学. 苗族药马蹄金化学成分的研究.天然产物研究与开发,2003,15(1):15-17.

46. 刘玉明,梁光义,张建新,武孔云,徐必学,罗波. 马蹄金化学成分的研究.中国药学杂志,2002,37(8):577-579.

专著:

 1. 刘玉明.《实用天然产物手册》萜类化合物分册(杨峻山主编)之第六章三环三萜类化合物,北京:化学工业出版社,2005.4 

专利: 

1. 刘玉明,范晶婧,艾双艳,冯亚东. 国家发明专利.全蝎中胍类生物碱钳蝎碱甲和/或钳蝎碱乙的提取方法及医药用途,授权专利号ZL201911232934.7

2. 刘玉明,孙琳娜,聂建兵,田丽珺.国家发明专利.少棘蜈蚣中喹啉类生物碱作为治疗肿瘤药品的制备及应用,授权专利号ZL201510029556.8

3. 刘玉明陈宝泉李彩文.国家发明专利.一种从杜仲果中提取桃叶珊瑚苷的工艺方法,授权专利号ZL201010297478.7

4. 刘玉明,孙琳娜,静.国家发明专利.一种从斯亚旦中提取异株五加甲苷的方法,申请号CN201310619087.6

5. 刘玉明,冯亚东,孙璐,聂建兵,路熹,孙琳娜.国家发明专利.常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备,申请号CN201410214316.0

6. 陈宝泉罗振华刘玉明史艳萍赵海川程吉赵婕.国家发明专利.2-(2-取代-1,3,4-噁二唑-5-基)-苯并异硒唑酮衍生物的制备方法,申请号CN201110411172.4

7. 陈宝泉史艳萍麻静卢学磊李彩文刘玉明.国家发明专利.基于苯并异硒唑酮结构的1,3,4-噻二唑(噁二唑)衍生物及其制备方法和应用,授权专利号ZL201010213585.7

8. 梁光义,徐必学,刘昌孝,黄正明,曹佩雪,蔡泽贵,刘玉明.国家发明专利.N-(N-苯甲酰基-苯丙氨酰基)-苯丙氨酸二肽衍生物及其制备方法和用途,授权专利号ZL200610201016.4

9. 梁光义,刘玉明,徐必学.国家发明专利.苯丙氨醇类化合物作为制备治疗乙肝药品的应用及其制备方法,授权专利号ZL02160309.X

获奖: 

1. 天津科技进步三等奖(2008年度),35种植物药标准提取物的研究。

 

 

 

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